Our Biomolecular Machines research program investigates the fundamental physics and mechanics of biological molecular motors, with a focus on understanding how these nanoscale machines convert chemical energy into mechanical work. Our research combines theoretical modeling, computational simulations, and experimental validation to explore the intricate dynamics of cellular transport systems.
Molecular Motors & Transport
Kinesin and Myosin Dynamics
Investigating how molecular motors like kinesin and myosin generate force and movement along cytoskeletal filaments. Our research examines motor protein mechanics, energy conversion efficiency, and collective motor behaviors.
Microtubule Mechanics
Cytoskeletal Dynamics
Studying the mechanical properties of microtubules and their interactions with motor proteins. We focus on filament persistence, gliding mechanics, and the relationship between structure and function in cellular transport.
Biosensor Applications
Technology Development
Developing biomolecular motor-powered biosensors and understanding how motor defects impact device performance. Our work bridges fundamental biology with practical nanotechnology applications.
Computational Modeling
Simulation & Theory
Creating mathematical models and computational simulations to predict molecular motor behavior, optimize biosensor designs, and understand complex transport phenomena in biological systems.
Our latest research investigates the active spiralling behavior of microtubules driven by kinesin motors. This work reveals new insights into how molecular motors can induce complex three-dimensional motion patterns in cytoskeletal filaments.
Key Findings:
We examine the fundamental relationship between path persistence and filament persistence lengths in microtubule gliding assays. This research provides crucial insights into how mechanical properties affect transport efficiency.
Research Highlights:
Our work investigates how defective molecular motors affect the performance of biomolecular motor-powered biosensors, providing critical insights for developing robust biotechnology applications.
Research Areas:
Active spiralling of microtubules driven by kinesin motors (2025)
Scientific Reports | DOI: 10.1038/s41598-025-03384-y
Investigation of novel spiral motion patterns in kinesin-driven microtubules and their implications for cellular organization.
Linking path and filament persistence lengths of microtubules gliding over kinesin (2022)
Scientific Reports | DOI: 10.1038/s41598-022-06941-x
Quantitative analysis of the relationship between different persistence measures in microtubule-motor systems.
Effects of defective motors on the active transport in biosensors powered by biomolecular motors (2022)
Biosensors and Bioelectronics | DOI: 10.1016/j.bios.2022.114011
Comprehensive study of how motor protein defects impact the performance of molecular motor-powered biosensors.
Motility resilience of molecular shuttles against defective motors (2022)
IEEE Transactions on NanoBioscience | DOI: 10.1109/tnb.2022.3170562
Analysis of resilience mechanisms in molecular transport systems under impaired motor conditions.
Modelling and Simulation of Biosensors Driven by Myosin Motors (2022)
Zenodo | DOI: 10.5281/ZENODO.5745872
Computational modeling framework for understanding myosin-powered biosensor systems.
Theoretical Modeling
Mathematical Frameworks
Computational Simulation
Simulation Tools
Data Analysis
Quantitative Methods
Experimental Validation
Laboratory Techniques
Our research continues to explore new frontiers in biomolecular machine physics:
Our biomolecular machines research program collaborates with leading institutions worldwide and contributes to both fundamental understanding and practical applications in biotechnology and medicine. Our work has implications for:
